A joint analysis of influenza-associated hospitalizations and mortality in Hong Kong, 1998–2013
Open Access
- 20 April 2017
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 7 (1), 1-7
- https://doi.org/10.1038/s41598-017-01021-x
Abstract
Influenza viruses may cause severe human infections leading to hospitalization or death. Linear regression models were fitted to population-based data on hospitalizations and deaths. Surveillance data on influenza virus activity permitted inference on influenza-associated hospitalizations and deaths. The ratios of these estimates were used as a potential indicator of severity. Influenza was associated with 431 (95% CrI: 358–503) respiratory deaths and 12,700 (95% CrI: 11,700–13,700) respiratory hospitalizations per year. Majority of the excess deaths occurred in persons ≥65 y of age. The ratios of deaths to hospitalizations in adults ≥65 y were significantly higher for influenza A(H1N1) and A(H1N1)pdm09 compared to A(H3N2) and B. Substantial disease burden associated with influenza viruses were estimated in Hong Kong particularly among children and elderly in 1998–2013. Infections with influenza A(H1N1) was suggested to be more serious than A(H3N2) in older adults.Keywords
This publication has 29 references indexed in Scilit:
- Hospitalization risk of the 2009 H1N1 pandemic cases in Hong KongBMC Infectious Diseases, 2014
- Influenza Infection and Risk of Acute Myocardial Infarction in England and Wales: A CALIBER Self-Controlled Case Series StudyThe Journal of Infectious Diseases, 2012
- Circulating Influenza Virus, Climatic Factors, and Acute Myocardial Infarction: A Time Series Study in England and Wales and Hong KongThe Journal of Infectious Diseases, 2011
- Complications and Outcomes of Pandemic 2009 Influenza A (H1N1) Virus Infection in Hospitalized Adults: How Do They Differ From Those in Seasonal Influenza?The Journal of Infectious Diseases, 2011
- Hospitalized Patients with 2009 Pandemic Influenza A (H1N1) Virus Infection in the United States—September–October 2009Clinical Infectious Diseases, 2011
- Elevated Influenza‐Related Excess Mortality in South African Elderly Individuals, 1998–2005Clinical Infectious Diseases, 2010
- The Pathology of Influenza Virus InfectionsAnnual Review Of Pathology-Mechanisms Of Disease, 2008
- Influenza-attributable deaths, Canada 1990–1999Epidemiology and Infection, 2007
- Influenza-Associated Hospitalization in a Subtropical CityPLoS Medicine, 2006
- Inference from Iterative Simulation Using Multiple SequencesStatistical Science, 1992