Detection rate of actionable mutations in diverse cancers using a biopsy-free (blood) circulating tumor cell DNA assay
Open Access
- 1 February 2016
- journal article
- Published by Impact Journals, LLC in Oncotarget
- Vol. 7 (9), 9707-9717
- https://doi.org/10.18632/oncotarget.7110
Abstract
// <![CDATA[ $('.header-date').hide();$('#titleAuthors').hide();$('#abstractHeader').hide(); // ]]> Maria Schwaederle1, Hatim Husain1, Paul T. Fanta1, David E. Piccioni1, Santosh Kesari1, Richard B. Schwab1, Kimberly C. Banks2, Richard B. Lanman2, AmirAli Talasaz2, Barbara A. Parker1, Razelle Kurzrock1 1Center for Personalized Cancer Therapy and Division of Hematology and Oncology, UCSD Moores Cancer Center, La Jolla, CA, USA 2Guardant Health, Inc., Redwood City, CA, USA Correspondence to: Maria Schwaederle, e-mail: mschwaederle@ucsd.edu Keywords: cancer, liquid biopsy, ctDNA, actionable alteration, personalized therapy Received: September 30, 2015 Accepted: January 23, 2016 Published: February 01, 2016Keywords
This publication has 36 references indexed in Scilit:
- Impact of a Biomarker-Based Strategy on Oncology Drug Development: A Meta-analysis of Clinical Trials Leading to FDA ApprovalJNCI Journal of the National Cancer Institute, 2015
- On the Road to Precision Cancer Medicine: Analysis of Genomic Biomarker Actionability in 439 PatientsMolecular Cancer Therapeutics, 2015
- Brain Tumor Mutations Detected in Cerebral Spinal FluidClinical Chemistry, 2015
- Enabling a Genetically Informed Approach to Cancer Medicine: A Retrospective Evaluation of the Impact of Comprehensive Tumor Profiling Using a Targeted Next-Generation Sequencing PanelThe Oncologist, 2014
- Detection of Circulating Tumor DNA in Early- and Late-Stage Human MalignanciesScience Translational Medicine, 2014
- Personalized Medicine in a Phase I Clinical Trials Program: The MD Anderson Cancer Center InitiativeClinical Cancer Research, 2012
- Breast cancer intratumor genetic heterogeneity: causes and implicationsExpert Review of Anticancer Therapy, 2012
- Understanding resistance to EGFR inhibitors—impact on future treatment strategiesNature Reviews Clinical Oncology, 2010
- Circulating mutant DNA to assess tumor dynamicsNature Medicine, 2008
- Complete Molecular Remission in Chronic Myelogenous Leukemia after Imatinib TherapyNew England Journal of Medicine, 2002