Abstract
Increasingly, society demands that long-standing disease-related problems be solved, but who will solve them? The opportunities are greater than in the past because of the great conceptual and technical advances in basic biologic science. There is every indication that such advances will continue to develop at an increasing rate. However, as science becomes more complicated, clinical scientists have greater difficulty in applying these advances to disease, and basic scientists are needed. The complexity of disease-related problems forms a spectrum. Many problems are so complex they exceed the ability of the traditional clinical scientist to deal with them; others are less . . .

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