The present and future role of microfluidics in biomedical research
Top Cited Papers
- 12 March 2014
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 507 (7491), 181-189
- https://doi.org/10.1038/nature13118
Abstract
Microfluidics, a technology characterized by the engineered manipulation of fluids at the submillimetre scale, has shown considerable promise for improving diagnostics and biology research. Certain properties of microfluidic technologies, such as rapid sample processing and the precise control of fluids in an assay, have made them attractive candidates to replace traditional experimental approaches. Here we analyse the progress made by lab-on-a-chip microtechnologies in recent years, and discuss the clinical and research areas in which they have made the greatest impact. We also suggest directions that biologists, engineers and clinicians can take to help this technology live up to its potential.Keywords
This publication has 100 references indexed in Scilit:
- Two-Dimensional Paper Network Format That Enables Simple Multistep Assays for Use in Low-Resource Settings in the Context of Malaria Antigen DetectionAnalytical Chemistry, 2012
- Purification of cell subpopulations via immiscible filtration assisted by surface tension (IFAST)Biomedical Microdevices, 2011
- Rapid Prototyping of Arrayed Microfluidic Systems in Polystyrene for Cell-Based AssaysAnalytical Chemistry, 2011
- Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effectsIntegrative Biology, 2011
- Engineered materials and the cellular microenvironment: a strengthening interface between cell biology and bioengineeringTrends in Cell Biology, 2010
- Clinical microfluidics for neutrophil genomics and proteomicsNature Medicine, 2010
- Microfluidics meet cell biology: bridging the gap by validation and application of microscale techniques for cell biological assaysBioEssays, 2008
- Managing evaporation for more robust microscale assays : Part 1. Volume loss in high throughput assaysLab on a Chip, 2008
- Characterization and Resolution of Evaporation-Mediated Osmolality Shifts That Constrain Microfluidic Cell Culture in Poly(dimethylsiloxane) DevicesAnalytical Chemistry, 2006
- The price of innovation: new estimates of drug development costsJournal of Health Economics, 2003