The role of mitochondrial dynamics in cardiovascular diseases
- 15 April 2020
- journal article
- review article
- Published by Wiley in British Journal of Pharmacology
- Vol. 178 (10), 2060-2076
- https://doi.org/10.1111/bph.15068
Abstract
The process of mitochondrial dynamics is emerging as a core player in cardiovascular homeostasis. This process refers to the coordinated cycles of biogenesis, fusion, fission and degradation to which mitochondria constantly undergo to maintain their integrity, distribution and size. These mechanisms represent an early response to mitochondrial stress, confining organelle portions that are irreversibly damaged and preserving mitochondrial function. Accumulating evidence demonstrates that impairment in mitochondrial dynamics leads to myocardial damage and cardiac disease progression in a variety of disease models, including pressure overload, ischemia/reperfusion and metabolic disturbance. These findings suggest that modulation of mitochondrial dynamics may be considered as a valid therapeutic strategy in cardiovascular diseases. In this review, we discuss the current evidence about the role of mitochondrial dynamics in cardiac pathophysiology, with a particular focus on the mechanisms underlying the development of cardiac hypertrophy and heart failure, metabolic and genetic cardiomyopathies, ischemia/reperfusion injury, atherosclerosis and ischemic stroke.Keywords
This publication has 146 references indexed in Scilit:
- Mitochondrial fission induced by platelet-derived growth factor regulates vascular smooth muscle cell bioenergetics and cell proliferationRedox Biology, 2013
- Dynasore Protects Mitochondria and Improves Cardiac Lusitropy in Langendorff Perfused Mouse HeartPLOS ONE, 2013
- SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemiaThe EMBO Journal, 2013
- Fine-Tuning of Drp1/Fis1 Availability by AKAP121/Siah2 Regulates Mitochondrial Adaptation to HypoxiaMolecular Cell, 2011
- Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia–reoxygenation stressCell Death & Differentiation, 2011
- Mitochondrial fragmentation and superoxide anion production in coronary endothelial cells from a mouse model of type 1 diabetesDiabetologia, 2010
- Dynamic organization of mitochondria in human heart and in myocardial diseaseThe International Journal of Biochemistry & Cell Biology, 2009
- PGC-1α and ERRα target gene downregulation is a signature of the failing human heartJournal of Molecular and Cellular Cardiology, 2009
- Doxorubicin Inactivates Myocardial Cytochrome c Oxidase in Rats: Cardioprotection by Mito-QBiophysical Journal, 2009
- Mitofusin 2 tethers endoplasmic reticulum to mitochondriaNature, 2008