Retroposed SNOfall—A mammalian-wide comparison of platypus snoRNAs
Open Access
- 7 May 2008
- journal article
- Published by Cold Spring Harbor Laboratory in Genome Research
- Vol. 18 (6), 1005-1010
- https://doi.org/10.1101/gr.7177908
Abstract
Diversification of mammalian species began more than 160 million years ago when the egg-laying monotremes diverged from live bearing mammals. The duck-billed platypus (Ornithorhynchus anatinus) and echidnas are the only potential contemporary witnesses of this period and, thereby, provide a unique insight into mammalian genome evolution. It has become clear that small RNAs are major regulatory agents in eukaryotic cells, and the significant role of non-protein-coding (npc) RNAs in transcription, processing, and translation is now well accepted. Here we show that the platypus genome contains more than 200 small nucleolar (sno) RNAs among hundreds of other diverse npcRNAs. Their comparison among key mammalian groups and other vertebrates enabled us to reconstruct a complete temporal pathway of acquisition and loss of these snoRNAs. In platypus we found cis- and trans-duplication distribution patterns for snoRNAs, which have not been described in any other vertebrates but are known to occur in nematodes. An exciting novelty in platypus is a snoRNA-derived retroposon (termed snoRTE) that facilitates a very effective dispersal of an H/ACA snoRNA via RTE-mediated retroposition. From more than 40,000 detected full-length and truncated genomic copies of this snoRTE, at least 21 are processed into mature snoRNAs. High-copy retroposition via multiple host gene-promoted transcription units is a novel pathway for combining housekeeping function and SINE-like dispersal and reveals a new dimension in the evolution of novel snoRNA function.Keywords
This publication has 25 references indexed in Scilit:
- Bov-B-mobilized SINEs in vertebrate genomesGene, 2008
- A Novel Class of Mammalian-Specific Tailless RetropseudogenesGenome Research, 2004
- Accumulation of Transposable Elements in the Genome of Drosophila melanogaster is Associated with a Decrease in FitnessJournal of Heredity, 2004
- Identification of 13 novel human modification guide RNAsNucleic Acids Research, 2003
- The origin of new genes: glimpses from the young and oldNature Reviews Genetics, 2003
- Evolutionary Dynamics and Evolutionary History in the RTE Clade of Non-LTR RetrotransposonsMolecular Biology and Evolution, 2001
- The 3′ ends of tRNA-derived SINEs originated from the 3’ ends of LINEs: A new example from the bovine genomeJournal of Molecular Evolution, 1997
- Rte‐1, a retrotransposon‐like element in Caenorhabditis elegansFEBS Letters, 1996
- Processing of fibrillarin-associated snoRNAs from pre-mRNA introns: An exonucleolytic process exclusively directed by the common stem-box terminal structureBiochimie, 1996
- Neural BC1 RNA: cDNA clones reveal nonrepetitive sequence content.Proceedings of the National Academy of Sciences of the United States of America, 1987