Inhibition of Rho-associated kinases suppresses cardiac myofibroblast function in engineered connective and heart muscle tissues
Open Access
- 21 June 2019
- journal article
- research article
- Published by Elsevier BV in Journal of Molecular and Cellular Cardiology
- Vol. 134, 13-28
- https://doi.org/10.1016/j.yjmcc.2019.06.015
Abstract
No abstract availableKeywords
Funding Information
- German Research Foundation
- DZHK (81X2300161)
- Cancer Research UK (C6620/A15961)
- DZHK
- German Research Foundation (DFG ZI 708/10-1, SFB 1002 TP C04, S01, SFB 937 TP A18, IRTG 1816 RP12)
This publication has 75 references indexed in Scilit:
- Transcriptome Analysis of PPARγ Target Genes Reveals the Involvement of Lysyl Oxidase in Human Placental Cytotrophoblast InvasionPLOS ONE, 2013
- Mechanism of fibrotic cardiomyopathy in mice expressing truncated Rho‐associated coiled‐coil protein kinase 1The FASEB Journal, 2012
- Transforming Growth Factor–β Induces Extracellular Matrix Protein Cross-Linking Lysyl Oxidase (LOX) Genes in Human Trabecular Meshwork CellsInvestigative Ophthalmology & Visual Science, 2011
- ROCK1 plays an essential role in the transition from cardiac hypertrophy to failure in miceJournal of Molecular and Cellular Cardiology, 2010
- Myocardin-Related Transcription Factor-A Controls Myofibroblast Activation and Fibrosis in Response to Myocardial InfarctionCirculation Research, 2010
- Rho kinase-1 mediates cardiac fibrosis by regulating fibroblast precursor cell differentiationCardiovascular Research, 2009
- Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatinBlood Coagulation & Fibrinolysis, 2008
- Comparative pharmacological analysis of Rho-kinase inhibitors and identification of molecular components of Ca2+ sensitization in the rat lower urinary tractBiochemical Pharmacology, 2007
- Cell Contact–dependent Regulation of Epithelial–Myofibroblast Transition via the Rho-Rho Kinase-Phospho-Myosin PathwayMolecular Biology of the Cell, 2007
- Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosisProceedings of the National Academy of Sciences of the United States of America, 2006