Assessment of varicella vaccine effectiveness in Germany: a time-series approach
- 15 December 2010
- journal article
- research article
- Published by Cambridge University Press (CUP) in Epidemiology and Infection
- Vol. 139 (11), 1710-1719
- https://doi.org/10.1017/s0950268810002815
Abstract
SUMMARY: A multivariate time-series regression model was developed in order to describe the 2005–2008 age-specific time-course of varicella sentinel surveillance data following the introduction of a varicella childhood vaccination programme in Germany. This ecological approach allows the assessment of vaccine effectiveness under field conditions by relating vaccine coverage in cohorts of 24-month-old children to the mean number of cases per reporting unit in the sentinel network. For the 1–2 years age group, which is directly affected by the vaccination programme, a one-dose vaccine effectiveness of 83·2% (95% CI 80·2–85·7) was estimated which corresponds to previous approaches assessing varicella vaccine effectiveness in the field in the USA.Keywords
This publication has 37 references indexed in Scilit:
- Varicella Prevention in the United States: A Review of Successes and ChallengesPediatrics, 2008
- Impact of universal varicella vaccination on 1-year-olds in Uruguay: 1997-2005Archives of Disease in Childhood, 2008
- Vaccination coverage in children can be estimated from health insurance dataBMC Public Health, 2008
- Changing Varicella Epidemiology in Active Surveillance Sites—United States, 1995–2005The Journal of Infectious Diseases, 2008
- Varicella Vaccine Effectiveness in the US Vaccination Program: A ReviewThe Journal of Infectious Diseases, 2008
- Metaanalysis of vaccine effectiveness in varicella outbreaksVaccine, 2007
- Loss of Vaccine-Induced Immunity to Varicella over TimeNew England Journal of Medicine, 2007
- The Case against Universal Varicella VaccinationInternational Journal of Toxicology, 2006
- Decline in Mortality Due to Varicella after Implementation of Varicella Vaccination in the United StatesNew England Journal of Medicine, 2005
- Estimation of Vaccine Effectiveness Using the Screening MethodInternational Journal of Epidemiology, 1993