Parkinsonism‐inducing neurotoxin MPP+: Uptake and toxicity in nonneuronal COS cells expressing dopamine transporter cDNA
- 1 July 1992
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 32 (1), 109-111
- https://doi.org/10.1002/ana.410320120
Abstract
Expression of a cloned dopamine transporter complementary DNA in COS cells allows these primate kidney cells to accumulate the parkinsonism‐inducing neurotoxin metabolite MPP+ (1‐methyl‐4‐phenylpyridinium) avidly, and MPP+ toxicity results. By documenting that the dopamine transporter can confer MPP+ sensitivity to nonneural cells, these results highlight the key role that this transporter could play in mechanisms underlying parkinsonism.Keywords
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