Binding characteristics of 3H-prazosin to rat brain α-adrenergic receptors
- 1 May 1979
- journal article
- research article
- Published by Elsevier BV in European Journal of Pharmacology
- Vol. 55 (3), 323-326
- https://doi.org/10.1016/0014-2999(79)90202-4
Abstract
3H-Prazosin binding to membranes from rat brain is saturable, Bmax, 77 fmol/mg protein, of high affinity, KD, 0.28 nM and with a drug specificity indicating that it labels alpha-adrenergic receptors. The ranking of alpha-antagonists for these binding sites suggests that 3H-prazosin may be useful in identifying a subpopulation of alpha-receptors (alpha1) in the central nervous system.Keywords
This publication has 3 references indexed in Scilit:
- Direct biochemical demonstration of two types of α-adrenoreceptor in rat brainNature, 1978
- Prazosin: differential affinities for two populations of α-noradrenergic receptor binding sitesEuropean Journal of Pharmacology, 1978
- Alpha-noradrenergic receptor binding in mammalian brain: Differential labeling of agonist and antagonist statesLife Sciences, 1976