Efficacy of Olyset®Duo, a permethrin and pyriproxyfen mixture net against wild pyrethroid-resistantAnopheles gambiae s.s.from Côte d’Ivoire: an experimental hut trial
Open Access
- 21 October 2015
- journal article
- research article
- Published by EDP Sciences in Parasite
- Vol. 22, 28
- https://doi.org/10.1051/parasite/2015028
Abstract
Pyrethroid resistance in malaria vectors has spread across sub-Saharan Africa. Alternative tools and molecules are urgently needed for effective vector control. One of the most promising strategies to prevent or delay the development of resistance is to use at least two molecules having unrelated modes of action in combination in the same bed net. We evaluated in experimental huts in Côte d’Ivoire, a new polyethylene long-lasting insecticidal net (LN) product, Olyset® Duo, incorporating permethrin (PER) and pyriproxyfen (PPF), an insect growth regulator (IGR). PPF alone or in combination with permethrin had a significant impact on fertility (7–12% reduction relative to control) and no effect on fecundity of wild multi-resistant An. gambiae s.s. These results triggered crucial research questions on the behaviour of targeted mosquitoes around the LN. To maximize the sterilizing effect of PPF in the combination, there would be a need for a trade-off between the necessary contact time of the insect with PPF and the surface content of the pyrethroid insecticide that is bioavailable and induces excito-repellency. La résistance aux pyréthrinoïdes est répandue chez les vecteurs du paludisme en Afrique sub-saharienne. Une des stratégies les plus prometteuses pour prévenir ou retarder l’évolution de la résistance est d’utiliser au moins deux molécules ayant des modes d’action indépendants en combinaison dans la même moustiquaire. Nous avons évalué en cases expérimentales en Côte d’Ivoire, une nouvelle moustiquaire à longue durée d’action (MILD) en polyéthylène, Olyset® Duo, associant la perméthrine (un insecticide pyréthrinoïde) et le pyriproxyfen (un inhibiteur de croissance). Le pyriproxyfen seul ou combiné à la perméthrine a induit une réduction significative de la fertilité (7-12 % de réduction par rapport au contrôle) mais n’a eu aucun effet sur la fécondité des femelles sauvages multi-résistantes. Ces résultats ont soulevé des questions cruciales de recherche sur le comportement des moustiques cibles face aux MILD. Pour maximiser l’effet stérilisant du PPF dans la combinaison, il y aurait un besoin de compromis entre le temps de contact nécessaire de l’insecte avec le PPF et le contenu de surface de l’insecticide pyréthrinoïde qui est biodisponible et induit l’excito-répulsion.Keywords
This publication has 23 references indexed in Scilit:
- Insecticide resistance status of Anopheles gambiae s.s population from M’Bé: a WHOPES-labelled experimental hut station, 10 years after the political crisis in Côte d’IvoireMalaria Journal, 2013
- Bioefficacy of long-lasting insecticidal nets against pyrethroid-resistant populations of Anopheles gambiae s.s. from different malaria transmission zones in UgandaParasites & Vectors, 2013
- Effects of pyrethroid resistance on the cost effectiveness of a mass distribution of long-lasting insecticidal nets: a modelling studyMalaria Journal, 2013
- Ascaris co-infection does not alter malaria-induced anaemia in a cohort of Nigerian preschool childrenMalaria Journal, 2013
- A user-friendly software to easily count Anopheles egg batchesParasites & Vectors, 2012
- Insecticide Control of Vector-Borne Diseases: When Is Insecticide Resistance a Problem?PLoS Pathogens, 2010
- Field efficacy of a new mosaic long-lasting mosquito net (PermaNet® 3.0) against pyrethroid-resistant malaria vectors: a multi centre study in Western and Central AfricaMalaria Journal, 2010
- Evaluation of PermaNet 3.0 a deltamethrin-PBO combination net against Anopheles gambiae and pyrethroid resistant Culex quinquefasciatus mosquitoes: an experimental hut trial in TanzaniaMalaria Journal, 2010
- Impact of insecticide-treated nets on wild pyrethroid resistant Anopheles epiroticus population from southern Vietnam tested in experimental hutsMalaria Journal, 2009
- Using adult mosquitoes to transfer insecticides to Aedes aegypti larval habitatsProceedings of the National Academy of Sciences of the United States of America, 2009