Haemostatic and inflammatory responses to blood flow‐restricted exercise in patients with ischaemic heart disease: a pilot study
- 30 July 2012
- journal article
- research article
- Published by Wiley in Clinical Physiology and Functional Imaging
- Vol. 33 (1), 11-17
- https://doi.org/10.1111/j.1475-097x.2012.01158.x
Abstract
Low-intensity resistance exercise can effectively induce muscle hypertrophy and increases in strength when combined with moderate blood flow restriction (BFR). As this type of exercise does not require lifting heavy weights, it might be a feasible method of cardiac rehabilitation, in which resistance exercise has been recommended to be included. Although previous studies with healthy subjects showed relative safety of BFR exercise, we cannot exclude the possibility of unfavourable effects in patients with cardiovascular disease. We therefore aimed to investigate haemostatic and inflammatory responses to BFR exercise in patients with ischaemic heart disease (IHD). Nine stable patients with IHD who were not taking anticoagulant drugs performed four sets of knee extension exercise at an intensity of 20% one-repetition maximum (1RM) either with or without BFR. Blood samples were taken before, immediately after and 1 h after the exercise session and analysed for noradrenaline, D-dimer, fibrinogen/fibrin degradation products (FDP) and high-sensitive C-reactive protein (hsCRP). Plasma noradrenaline concentration increased after the exercise, and the increase was significantly larger after the exercise with BFR than without BFR. On the other hand, increases in concentrations of plasma D-dimer and serum hsCRP were independent of the condition. However, increases in D-dimer and hsCRP were no longer observed after plasma volume correction, suggesting that hemoconcentration was responsible for these increases. Plasma FDP concentration did not change after the exercise. These results suggest that applying BFR during low-intensity resistance exercise does not affect exercise-induced haemostatic and inflammatory responses in stable IHD patients.Keywords
This publication has 36 references indexed in Scilit:
- Relationship between limb and trunk muscle hypertrophy following high‐intensity resistance training and blood flow–restricted low‐intensity resistance trainingClinical Physiology and Functional Imaging, 2011
- Potential safety issues with blood flow restriction trainingScandinavian Journal of Medicine & Science in Sports, 2011
- Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older menJournal of Applied Physiology, 2010
- Effects of Leg Blood Flow Restriction during Walking on Cardiovascular FunctionMedicine & Science in Sports & Exercise, 2010
- Effects of low‐intensity resistance exercise with blood flow restriction on coagulation system in healthy subjectsClinical Physiology and Functional Imaging, 2010
- The Use of Occlusion Training to Produce Muscle HypertrophyStrength and Conditioning Journal, 2009
- Ischemic strength training: a low‐load alternative to heavy resistance exercise?Scandinavian Journal of Medicine & Science in Sports, 2008
- Effects of KAATSU training on haemostasis in healthy subjectsInternational Journal of KAATSU Training Research, 2007
- Exercise-Induced Changes in Coagulation and Fibrinolysis in Healthy Populations and Patients with Cardiovascular DiseaseSports Medicine, 2003
- Assessment of hypercoagulable states by measurement of activation fragments and peptidesBlood Reviews, 1990