Oscillations of Membrane Current and Excitability Driven by Metabolic Oscillations in Heart Cells
- 12 August 1994
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 265 (5174), 962-966
- https://doi.org/10.1126/science.8052856
Abstract
Periodic changes in membrane ionic current linked to intrinsic oscillations of energy metabolism were identified in guinea pig cardiomyocytes. Metabolic stress initiated cyclical activation of adenosine triphosphate-sensitive potassium current and concomitant suppression of depolarization-evoked intracellular calcium transients. The oscillations in membrane current and excitation-contraction coupling were linked to oscillations in the oxidation state of pyridine nucleotides but were not driven by pacemaker currents or alterations in the concentration of cytosolic calcium. Interventions that altered the rate of glucose metabolism modulated the oscillations, suggesting that the rhythms originated at the level of glycolysis. The energy-driven oscillations in potassium currents produced cyclical changes in the cardiac action potential and thus may contribute to the genesis of arrhythmias during metabolic compromise.Keywords
This publication has 31 references indexed in Scilit:
- Calcium Channels, Stores, and OscillationsAnnual Review of Cell Biology, 1990
- Effects of insulin on glucose metabolism in isolated heart myocytes from adult ratsBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1985
- Chaotic dynamics in yeast glycolysis under periodic substrate input fluxFEBS Letters, 1984
- REVIEWHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1983
- Relaxation of muscle fibres by photolysis of caged ATPNature, 1982
- Oscillations of the glycolytic pathway and the purine nucleotide cycleJournal of Theoretical Biology, 1979
- TEMPORAL AND SPATIAL ORDER IN BIOCHEMICAL SYSTEMSAnnals of the New York Academy of Sciences, 1979
- Oscillations in calcium-cyclic AMP control loops form the basis of pacemaker activity and other high frequency biological rhythmsJournal of Theoretical Biology, 1977
- Oscillatory systems in mitochondriaBiochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics, 1974
- Oscillations of glycolytic intermediates in yeast cellsBiochemical and Biophysical Research Communications, 1964