“Composite” Tumor—Mixed Squamous Cell and Small‐Cell Anaplastic Carcinoma of the Larynx
- 1 July 1986
- journal article
- case report
- Published by Wiley in Otolaryngology -- Head and Neck Surgery
- Vol. 95 (1), 99-103
- https://doi.org/10.1177/019459988609500119
Abstract
Mixed squamous and oat cell carcinomas (composite neoplasms) of the larynx behave aggressively with a propensity toward early dissemination. Diagnosis may not be made until definitive surgery is performed. The extent of surgery must be determined by the size and site of the primary neoplasm and the physiologic status of the patient. In our experience, surgery has adequately controlled the primary disease. A metastatic work-up is essential. Entry into a comprehensive program employing adjunctive radiotherapy and chemotherapy are strongly recommended. Theories concerning histogenesis remain controversial and include two separate colliding tumors, differentiation from a single cell line, or divergent differentiation of a single cell line.Keywords
This publication has 13 references indexed in Scilit:
- Small-cell carcinoma of the lungThe American Journal of Surgical Pathology, 1983
- Small cell tumors of the lungThe American Journal of Surgical Pathology, 1983
- Oat Cell Carcinoma of LarynxJAMA Otolaryngology–Head & Neck Surgery, 1981
- Prim res Doppelkarzinom an Kehlkopf und Hypopharynx mit unterschiedlicher HistologieEuropean Archives of Oto-Rhino-Laryngology, 1980
- Small cell squamous and mixed small cell squamous—small cell anaplastic carcinomas of the lungThe American Journal of Surgical Pathology, 1980
- Simultaneous Primary Oat Cell Carcinoma (Apudoma) and Squamous Cell Carcinoma of the HypopharynxORL, 1980
- Ultrastructural and biochemical analysis of “undifferentiated” pulmonary carcinomasHuman Pathology, 1978
- Primary oat-cell carcinoma of the larynxVirchows Archiv A Pathological Anatomy and Histopathology, 1978