Pathologic Findings in the Adrenal Glands of Autopsied Patients with Acquired Immunodeficiency Syndrome
- 1 January 2002
- journal article
- Published by Elsevier BV in Pathology - Research and Practice
- Vol. 198 (1), 25-30
- https://doi.org/10.1078/0344-0338-00180
Abstract
A morphologic evaluation was carried out on adrenal glands from 128 autopsied patients with the acquired immunodeficiency syndrome (AIDS). The adrenal gland was compromised in 99.2% of the cases, with distinct pathological features and infectious agents. Inflammatory infiltrates were observed in 99.2% of the cases with a predominance of mononuclear cells in 97.4%, affecting mainly the medulla. Necrosis, fibrosis, hemorrhages and neoplasias were observed. We also described 3 (2.3%) cases of calcification located in the adrenal gland central vein (AGCV). This is seldom mentioned in the literature. Cytomegalovirus was the most frequent infectious agent, observed in 48.4% of cases. Balamuthia mandrillaris, a free living ameba, was found in one case affecting the entire gland. We also found a nest of Trypanosoma cruzi in the musculature of the AGCV. The presence of the nest of T cruzi in AGCV may play a role in the reactivation of this infection in immunosuppressed individuals. Pathologic processes and opportunistic infections may contribute to the alterations in the adrenal gland that lead to multiple organ failure observed in terminal AIDS patients.Keywords
This publication has 16 references indexed in Scilit:
- Thrombotic Microangiopathy in the HIV-2-Infected MacaqueThe American Journal of Pathology, 1999
- Autopsy Findings in the Acquired Immunodeficiency Syndrome (AIDS). A Report of 395 Cases from the South of FrancePathology - Research and Practice, 1999
- Cytomegalovirus (CMV) retinitis and CMV antigenemia as a clue to impaired adrenocortical function in patients with AIDSAIDS, 1997
- Adrenal Insufficiency in a Patient with Acquired Immunodeficiency Syndrome.Endocrine Journal, 1994
- Adrenocortical insufficiency with normal serum cortisol levels and hyporeninaemia in a patient with acquired immunodeficiency syndrome (AIDS)Journal of Internal Medicine, 1991
- Cytomegaloviral Adrenalitis and Adrenal Insufficiency in AIDSAmerican Journal of Clinical Pathology, 1990
- The Growing Spectrum of HIV-Related Endocrine AbnormalitiesJournal of Clinical Endocrinology & Metabolism, 1990
- Pathology of Mycobacterium aviumintracellulare infection in acquired immunodeficiency syndromeHuman Pathology, 1987
- Adrenal Pathology in the Acquired Immune Deficiency SyndromeAmerican Journal of Clinical Pathology, 1985
- Adrenal cortico-medullary junction necrosis: a morphologic marker for hypotensionAmerican Heart Journal, 1979