Liver transplantation and autoimmune liver diseases
- 13 August 2013
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Liver Transplantation
- Vol. 19 (10), 1065-1077
- https://doi.org/10.1002/lt.23704
Abstract
Liver transplantation (LT) is an effective treatment for patients with end‐stage autoimmune liver diseases such as primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis. Indications for LT for these diseases do not differ substantially from those used for other acute or chronic liver diseases. Despite the good outcomes reported, the recurrence of autoimmune liver disease is relatively common in the allograft. In addition, it has become apparent that autoimmunity and autoimmune liver disease can arise de novo after transplantation for nonautoimmune liver disorders. An awareness of the existence of recurrent autoimmune liver diseases and de novo autoimmune hepatitis after LT has important clinical implications because their management differs from the standard antirejection treatment and is similar to the management of classic autoimmune liver diseases in the native liver. Liver Transpl 19:1065‐1077, 2013. © 2013 AASLD.Keywords
Funding Information
- Rodrigo Liberal was supported by a doctoral grant from the Foundation for Science and Technology in Lisbon, Portugal (SFRH/BD/65007/2009)
This publication has 98 references indexed in Scilit:
- Pathogenesis of primary sclerosing cholangitisBest Practice & Research Clinical Gastroenterology, 2011
- Liver transplantation in PBC and PSC: Indications and disease recurrenceClinics and Research in Hepatology and Gastroenterology, 2011
- Risk factors for recurrence of primary sclerosing cholangitis after liver transplantationLiver Transplantation, 2008
- Corticosteroids or not in severe acute or fulminant autoimmune hepatitis: Therapeutic brinksmanship and the point beyond salvationLiver Transplantation, 2007
- Impairment of CD4+CD25+ regulatory T-cells in autoimmune liver diseaseJournal of Hepatology, 2004
- International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitisJournal of Hepatology, 1999
- Recurrence of primary biliary cirrhosis in the liver allograft: the effect of immunosuppressionJournal of Hepatology, 1996
- Primary biliary cirrhosis: Histological evidence of disease recurrence after liver transplantationJournal of Hepatology, 1993
- Recurrence of primary biliary cirrhosis after liver transplantation following FK506-based immunosuppressionJournal of Hepatology, 1993
- Recurrence of Primary Biliary Cirrhosis after Liver TransplantationThe New England Journal of Medicine, 1982