Clinical Utility of a Fingerstick Technology to Identify Individuals with Abnormal Blood Lipids and High-Sensitivity C-Reactive Protein Levels
- 1 March 2009
- journal article
- research article
- Published by SAGE Publications in American Journal of Health Promotion
- Vol. 23 (4), 279-282
- https://doi.org/10.4278/ajhp.071221140
Abstract
Purpose. The purpose of this study was to determine the ability of a commonly used fingerstick technology to identify individuals with abnormal blood levels of total cholesterol (TC), calculated low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), and high-sensitivity C-reactive protein (hsCRP) compared with a standardized laboratory. Methods. Participants (n = 250; mean age, 48.0 + 13.5 years; 66% female; 36% nonwhite) were eligible for primary prevention of cardiovascular disease (CVD). Blood lipids and hsCKP were measured simultaneously by (1) fingerstick analyzed by Cholestech LDX analyzers and (2) fresh venous blood that was analyzed by Columbia University General Clinical Research Center (GCRC) Core Laboratory. Pearson correlation coefficients, kappa, sensitivity, and specificity were calculated for fingerstick versus GCRC laboratory values for lipids and hsCRP. Results. The correlations between fingerstick and core laboratory for TC, LDL-C, HDL-C, TG, and hsCRP were .91, .88, .77, .93, and .81, respectively (all p < .01). Sensitivity and specificity of the fingerstick to identify those with abnormal lipids and hsCRP ≥ 1 mg/L were all ≥ 75%. Conclusion. Fingerstick screening is accurate and has good clinical utility to identify persons with abnormal blood lipids and hsCRP at the point of care in a diverse population that is eligible for primary prevention of CVD. These results may not be generalizable to patients at high risk for CVD or who have known hyperlipidemia.Keywords
This publication has 10 references indexed in Scilit:
- Heart Disease and Stroke Statistics—2007 UpdateCirculation, 2007
- Validation of a point of care lipid analyser using a hospital based reference laboratoryIrish Journal of Medical Science, 2006
- Performance of the CardioChek PA and Cholestech LDX point-of-care analysers compared to clinical diagnostic laboratory methods for the measurement of lipids.2005
- Markers of Inflammation and Cardiovascular DiseaseCirculation, 2003
- Inaccuracy of Lipid Measurements with the Portable Cholestech L·D·X Analyzer in Patients with HypercholesterolemiaClinical Chemistry, 2002
- Evaluation of Lipid Profile Measurements Obtained From the Cholestech L??D??X AnalyzerJournal of Cardiopulmonary Rehabilitation, 1997
- National Cholesterol Education Program recommendations for measurement of low-density lipoprotein cholesterol: executive summary. The National Cholesterol Education Program Working Group on Lipoprotein MeasurementClinical Chemistry, 1995
- Evaluation of the Cholestech L.D.X. desktop analyser for cholesterol, HDL-cholesterol, and triacylglycerols in heparinized venous blood.1994
- Evaluation of seven Cholestech L.D.X analyzers for total cholesterol determinationsClinical Chemistry, 1993
- Reflotron Performance in a Community Screening Program: Results of the Massachusetts Model Systems for Blood Cholesterol Screening ProjectAmerican Journal of Preventive Medicine, 1991