Relationships between plasma leptin levels, leptin G2548A, leptin receptor Gln223Arg polymorphisms and gestational diabetes mellitus in Chinese population
Open Access
- 1 April 2016
- journal article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 6 (1), 23948
- https://doi.org/10.1038/srep23948
Abstract
The purposes of this study were to examine concentrations of leptin and biochemical parameters in gestational diabetes mellitus (GDM) patients and normal glucose tolerance (NGT) individuals, and also to explore the links of leptin (LEP) G2548A and leptin receptor (LEPR) Gln223Arg polymorphisms with leptin levels and GDM risk among Chinese. Our study included 357 GDM and 355 NGT individuals who were at 24~30 gestational weeks. Plasma leptin and insulin levels were analyzed by ELISA. Gene polymorphisms were genotyped using TaqMan real-time polymerase chain reaction assay. The results showed that plasma leptin levels were significantly higher in the impaired fasting glucose (IFG) group than NGT group (34.35 (26.54, 56.48) ng/mL vs 26.31 (17.99, 37.87) ng/mL, P < 0.05). Plasma leptin levels correlated with plasma fasting insulin levels, pre-pregnant body mass index, homeostasis model assessment-insulin resistance and quantitative insulin sensitivity check index both in GDM and NGT group (P < 0.05). However, neither LEP G2548A nor LEPR Gln223Arg polymorphisms were significantly associated with GDM risk and plasma leptin levels (P > 0.05). Our findings showed that high leptin level was associated with GDM. And larger and more rigorous researches were needed to further explore the association of LEP and LEPR gene polymorphisms and GDM among Chinese population.This publication has 41 references indexed in Scilit:
- The serum leptin level and body mass index in Melanesian and Micronesian Solomon Islanders: Focus on genetic factors and urbanizationAmerican Journal of Human Biology, 2010
- International Association of Diabetes and Pregnancy Study Groups Recommendations on the Diagnosis and Classification of Hyperglycemia in PregnancyDiabetes Care, 2010
- Leptin G-2548A and leptin receptor Q223R gene polymorphisms are not associated with obesity in Romanian subjectsBiochemical and Biophysical Research Communications, 2010
- Diagnosis of gestational diabetes mellitus by use of the homeostasis model assessment–insulin resistance index in the first trimesterGynecological Endocrinology, 2008
- Association of leptin genetic polymorphism -2548 G/A with gestational diabetes mellitusGenes & Nutrition, 2006
- Differences in insulin sensitivity in pregnant women with overweight and gestational diabetes mellitusGynecological Endocrinology, 2006
- Increased Maternal Plasma Leptin in Early Pregnancy and Risk of Gestational Diabetes MellitusObstetrics & Gynecology, 2004
- A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumferenceInternational Journal of Obesity, 2002
- Modulation of Insulin Activities by LeptinScience, 1996
- Positional cloning of the mouse obese gene and its human homologueNature, 1994