Scaffolding Catalysts: Highly Enantioselective Desymmetrization Reactions
- 7 July 2011
- journal article
- research article
- Published by Wiley in Angewandte Chemie-International Edition
- Vol. 50 (35), 8167-8171
- https://doi.org/10.1002/anie.201103470
Abstract
Ex‐changing places: A highly enantioselective desymmetrization of 1,2‐diols has been developed in which the catalyst utilizes reversible covalent bonding to the substrate to achieve both high selectivity and rate acceleration (see scheme, PMP=pentalmethylpiperidine, TBS=tert‐butyldimethylsilyl). Induced intramolecularity is responsible for the enhanced rate, thus allowing the reaction to be performed at room temperature.Keywords
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