Membrane Signaling Induced by High Doses of Ionizing Radiation in the Endothelial Compartment. Relevance in Radiation Toxicity
Open Access
- 17 November 2013
- journal article
- review article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 14 (11), 22678-22696
- https://doi.org/10.3390/ijms141122678
Abstract
Tumor areas can now be very precisely delimited thanks to technical progress in imaging and ballistics. This has also led to the development of novel radiotherapy protocols, delivering higher doses of ionizing radiation directly to cancer cells. Despite this, radiation toxicity in healthy tissue remains a major issue, particularly with dose-escalation in these new protocols. Acute and late tissue damage following irradiation have both been linked to the endothelium irrigating normal tissues. The molecular mechanisms involved in the endothelial response to high doses of radiation are associated with signaling from the plasma membrane, mainly via the acid sphingomyelinase/ceramide pathway. This review describes this signaling pathway and discusses the relevance of targeting endothelial signaling to protect healthy tissues from the deleterious effects of high doses of radiation.Keywords
This publication has 106 references indexed in Scilit:
- Requirement of translocated lysosomal V1 H+-ATPase for activation of membrane acid sphingomyelinase and raft clustering in coronary endothelial cellsMolecular Biology of the Cell, 2012
- Sphingosine-1-phosphate signaling and its role in diseaseTrends in Cell Biology, 2011
- Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomesThe EMBO Journal, 2010
- Syntaxin 4 Is Required for Acid Sphingomyelinase Activity and Apoptotic FunctionPublished by Elsevier BV ,2010
- Effect of Irradiation on Microvascular Endothelial Cells of Parotid Glands in the Miniature PigInternational Journal of Radiation Oncology*Biology*Physics, 2010
- Activation of Membrane NADPH Oxidase Associated with Lysosome-Targeted Acid Sphingomyelinase in Coronary Endothelial CellsAntioxidants and Redox Signaling, 2010
- Sphingomyelin metabolism at the plasma membrane: Implications for bioactive sphingolipidsFEBS Letters, 2009
- NADPH oxidase mediates radiation-induced oxidative stress in rat brain microvascular endothelial cellsFree Radical Biology & Medicine, 2008
- Anti-Inflammatory Effects of Statins: Clinical Evidence and Basic MechanismsNature Reviews Drug Discovery, 2005
- Secretory Sphingomyelinase, a Product of the Acid Sphingomyelinase Gene, Can Hydrolyze Atherogenic Lipoproteins at Neutral pH: IMPLICATIONS FOR ATHEROSCLEROTIC LESION DEVELOPMENTPublished by Elsevier BV ,1998