Placental-like alkaline phosphatase: Re-evaluation of the tumor marker with exclusion of smokers
- 15 October 1986
- Vol. 58 (8), 1689-1694
- https://doi.org/10.1002/1097-0142(19861015)58:8<1689::aid-cncr2820580818>3.0.co;2-q
Abstract
This report demonstrates that smoking is a major factor of nonspecific elevation of the tumor marker placental-like alkaline phosphatase (PLAP). In 98 healthy nonsmokers the mean of the enzyme activity was determined as 0.068 U/L (range, ±2 SD 0–0.144 U/L) compared to a mean of 0378 U/L (range, ±2 SD 0–1.02 U/L) in 65 smokers. In view of this finding the usefulness of PLAP as a tumor marker was re-evaluated in 286 patients with various neoplasms and a negative smoking history. Of these patients, 23% and 50% had elevated values for PLAP and carcinoembryonic antigen, respectively. When compared to the range of PLAP in normal smokers only 4.1% of the patients showed elevated values. An increased incidence of elevated PLAP was found in patients with tumors of the lung, pancreas, stomach, colon/ rectum, ovaries, and in 2 of 3 seminomas. It was concluded from the data that PLAP is a useful tumor marker for selected neoplasms provided its use is confined to nonsmokers.Keywords
This publication has 11 references indexed in Scilit:
- Sensitive fluorometry of heat-stable alkaline phosphatase (Regan enzyme) activity in serum from smokers and nonsmokers.Clinical Chemistry, 1983
- Elevation of serum placental alkaline phosphatase levels in cigarette smokersInternational Journal of Cancer, 1983
- Placental alkaline phosphatase, alphafetoprotein and carcinoembryonic antigen in testicular tumors. Tissue typing by means of cytologic smearsInternational Journal of Cancer, 1979
- Demonstration of placental alkaline phosphatase in human breast cancerInternational Journal of Cancer, 1979
- Placental-like alkaline phosphatase in malignant and benign ovarian tumorsClinica Chimica Acta; International Journal of Clinical Chemistry, 1978
- Regan variant alkaline phosphatase in gastrointestinal carcinomaClinica Chimica Acta; International Journal of Clinical Chemistry, 1978
- Community Control of HypertensionAustralian and New Zealand Journal of Medicine, 1976
- Carcinoembryonic antigen (CEA) assayA laboratory adjunct in the diagnosis and management of cancerHuman Pathology, 1974
- INCREASED CARCINOEMBRYONIC ANTIGEN IN HEAVY CIGARETTE SMOKERSThe Lancet, 1973
- New observations on the Regan isoenzyme of alkaline phosphatase in cancer patientsCancer, 1971