An early haematopoietic defect in mice lacking the transcription factor GATA-2
- 15 September 1994
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 371 (6494), 221-226
- https://doi.org/10.1038/371221a0
Abstract
Blood cell development relies on the expansion and maintenance of haematopoietic stem and progenitor cells in the embryo. By gene targeting in mouse embryonic stem cells, we demonstrate that the transcription factor GATA-2 plays a critical role in haematopoiesis, particularly of an adult type. We propose that GATA-2 regulates genes controlling growth factor responsiveness or the proliferative capacity of early haematopoietic cells.Keywords
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