Becoming a new neuron in the adult olfactory bulb
Top Cited Papers
- 21 April 2003
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Neuroscience
- Vol. 6 (5), 507-518
- https://doi.org/10.1038/nn1048
Abstract
New neurons are continually recruited throughout adulthood in certain regions of the adult mammalian brain. How these cells mature and integrate into preexisting functional circuits remains unknown. Here we describe the physiological properties of newborn olfactory bulb interneurons at five different stages of their maturation in adult mice. Patch-clamp recordings were obtained from tangentially and radially migrating young neurons and from neurons in three subsequent maturation stages. Tangentially migrating neurons expressed extrasynaptic GABAA receptors and then AMPA receptors, before NMDA receptors appeared in radially migrating neurons. Spontaneous synaptic activity emerged soon after migration was complete, and spiking activity was the last characteristic to be acquired. This delayed excitability is unique to cells born in the adult and may protect circuits from uncontrolled neurotransmitter release and neural network disruption. Our results show that newly born cells recruited into the olfactory bulb become neurons, and a unique sequence of events leads to their functional integration.Keywords
This publication has 45 references indexed in Scilit:
- Maturation and Death of Adult-Born Olfactory Bulb Granule Neurons: Role of OlfactionJournal of Neuroscience, 2002
- Functional Integration of Adult-Born NeuronsCurrent Biology, 2002
- Neurogenesis in the Adult BrainJournal of Neuroscience, 2002
- Why Are Some Neurons Replaced in Adult Brain?Journal of Neuroscience, 2002
- Neurogenesis in Adult Subventricular ZoneJournal of Neuroscience, 2002
- Unique neuronal tracers show migration and differentiation of SVZ progenitors in organotypic slicesJournal of Neurobiology, 2001
- Long-Distance Neuronal Migration in the Adult Mammalian BrainScience, 1994
- Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zoneNeuron, 1993
- Golgi studies on the development of granule cells of the rat olfactory bulb with reference to migration in the subependymal layerJournal of Comparative Neurology, 1987
- Neurons Generated in the Adult Brain Are Recruited into Functional CircuitsScience, 1984