Changes in blood enzyme activities and some liver parameters in goats with subclinical ketosis

Abstract

The aim of the present study was to establish the changes in blood enzyme activities and some liver parameters in goats from the Saanen breed in different physiological conditions with subclinical ketosis (SCK). A total of 113 dairy goats with yearly milk yield of 680 L, in their 2nd to 3rd lactation were included in the study. The goats were divided in three groups: pregnant; recently kidded and lactating. Blood samples were obtained from all animals for determination of β-hydroxybutyrate (ВНВА), glucose (mmol/L), aspartate aminotransferase (ASAT, U/L), alanine aminotransferase (ALAT, U/L), lactate dehydrogenase (LDH, U/L), alkaline phosphatase (AР, U/L), creatine kinase (CK, U/L), γ-glutamyltransferase (GGT, U/L), total protein (TP, g/L), albumin (ALB, g/L) and total bilirubin (TB, μmol/L). The animals were classified as healthy (control) and with SCK according to their blood BHBA levels. Blood BHBA concentrations indicative for clinical ketosis (ВНВА <1.6 mmol/L) were not established in goats from the three groups. Blood biochemical analysis of activities of ASAT, ALAT, LDH, АP, CK and GGT in goats from the three groups with SCK demonstrated a various extent of statistically significant hyperenzymaemia vs control groups. The concentrations of total bilirubin were statistically significantly elevated vs healthy groups, while blood glucose, total protein and albumin values decreased, in result of the impaired liver function in goats with SCK.