Development of the Primary Antibody Repertoire
- 20 November 1987
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 238 (4830), 1079-1087
- https://doi.org/10.1126/science.3317825
Abstract
The ability to generate a diverse immune response depends on the somatic assembly of genes that encode the antigen-binding portions of immunoglobulin molecules. In this article, we discuss the mechanism and control of these genomic rearrangement events and how aspects of this process are involved in generating the primary antibody repertoire.Keywords
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