Getting down to the phosphorylated ‘nuts and bolts’ of spindle checkpoint signalling
- 31 January 2010
- journal article
- review article
- Published by Elsevier BV in Trends in Biochemical Sciences
- Vol. 35 (1), 18-27
- https://doi.org/10.1016/j.tibs.2009.09.002
Abstract
Due to the highly orchestrated stages of mitosis, cells segregate their chromosomes with incredibly high fidelity. One of the principal 'conductors' is the spindle checkpoint, which regulates mitotic progression. Specifically, it delays anaphase onset until all chromosomes are attached in a bi-oriented fashion to spindle microtubules. This delay stems from inhibition of Cdc20, an activator of an E3 ubiquitin ligase known as the anaphase-promoting complex or cyclosome (APC/C). Several recent advances in our mechanistic understanding of this important cell cycle control have been made. Although still poorly understood, signalling roles for checkpoint kinases and their opposing phosphatases continue to be uncovered, and the key substrates gradually identified.Keywords
This publication has 80 references indexed in Scilit:
- Boveri revisited: chromosomal instability, aneuploidy and tumorigenesisNature Reviews Molecular Cell Biology, 2009
- Bi-orienting chromosomes: acrobatics on the mitotic spindleChromosoma, 2008
- Linking Kinetochore-Microtubule Binding to the Spindle CheckpointDevelopmental Cell, 2008
- Molecular architecture of the kinetochore–microtubule interfaceNature Reviews Molecular Cell Biology, 2008
- The Mad2 Conformational Dimer: Structure and Implications for the Spindle Assembly CheckpointCell, 2007
- The spindle-assembly checkpoint in space and timeNature Reviews Molecular Cell Biology, 2007
- The anaphase promoting complex/cyclosome: a machine designed to destroyNature Reviews Molecular Cell Biology, 2006
- The Mad1/Mad2 Complex as a Template for Mad2 Activation in the Spindle Assembly CheckpointCurrent Biology, 2005
- Mitotic forces control a cell-cycle checkpointNature, 1995
- Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle.The Journal of cell biology, 1994