Intravascular Ultrasound (IVUS): A Potential Arthroscopic Tool for Quantitative Assessment of Articular Cartilage
Open Access
- 26 June 2009
- journal article
- Published by Bentham Science Publishers Ltd. in The Open Biomedical Engineering Journal
- Vol. 3 (1), 13-20
- https://doi.org/10.2174/1874120700903010013
Abstract
Conventional ultrasound examination of the articular cartilage performed externally on the body surface around the joint has limited accuracy due to the inadequacy in frequency used. In contrast to this, minimally invasive arthroscopy-based ultrasound with adequately high frequency may be a better alternative to assess the cartilage. Up to date, no special ultrasound transducer for imaging the cartilage in arthroscopic use has been designed. In this study, we introduced the intravascular ultrasound (IVUS) for this purpose. An IVUS system with a catheter-based probe (Ø ≈ 1mm) was used to measure the thickness and surface acoustical reflection of the bovine patellar articular cartilagein vitrobefore and after degeneration induced by enzyme treatments. Similar measurement was performed using another high frequency ultrasound system (Vevo) with a probe of much larger size and the results were compared between the two systems. The thickness measured using IVUS was highly correlated (r = 0.985, p < 0.001) with that obtained by Vevo. Thickness and surface reflection amplitude measured using IVUS on the enzymatically digested articular cartilage showed changes similar to those obtained by Vevo, which were expectedly consistent with previous investigations. IVUS can be potentially used for the quantitative assessment of articular cartilage, with its ready-to-use arthroscopic feature.Keywords
This publication has 40 references indexed in Scilit:
- Ultrasound in the study and monitoring of osteoarthritisOsteoarthritis and Cartilage, 2008
- More intrinsic parameters should be used in assessing degeneration of articular cartilage with quantitative ultrasoundArthritis Research & Therapy, 2008
- Imaging articular cartilage under compression—cartilage elastographyMagnetic Resonance in Medicine, 2005
- Validation of a 40MHz B-scan ultrasound biomicroscope for the evaluation of osteoarthritis lesions in an animal modelOsteoarthritis and Cartilage, 2005
- Simultaneous measurements of the ultrasonic wave velocity and thickness of a solid plate made from one side of the plateMeasurement Science and Technology, 2003
- Novel mechano-acoustic technique and instrument for diagnosis of cartilage degenerationPhysiological Measurement, 2002
- An in situ calibration of an ultrasound transducer:: a potential application for an ultrasonic indentation test of articular cartilageJournal of Biomechanics, 2001
- Collagenase: a key enzyme in collagen turnoverBiochemistry and Cell Biology, 1996
- Imaging of immature articular cartilage using ultrasound backscatter microscopy at 50 MHzJournal of Orthopaedic Research, 1995
- Effects of proteolytic enzymes on structural and mechanical properties of cartilageArthritis & Rheumatism, 1972