Maternal Zinc Intakes and Homeostatic Adjustments during Pregnancy and Lactation
Open Access
- 23 July 2012
- Vol. 4 (7), 782-798
- https://doi.org/10.3390/nu4070782
Abstract
Zinc plays critical roles during embryogenesis, fetal growth, and milk secretion, which increase the zinc need for pregnancy and lactation. Increased needs can be met by increasing the dietary zinc intake, along with making homeostatic adjustments in zinc utilization. Potential homeostatic adjustments include changes in circulating zinc, increased zinc absorption, decreased zinc losses, and changes in whole body zinc kinetics. Although severe zinc deficiency during pregnancy has devastating effects, systematic reviews and meta-analysis of the effect of maternal zinc supplementation on pregnancy outcomes have consistently shown a limited benefit. We hypothesize, therefore, that zinc homeostatic adjustments during pregnancy and lactation improve zinc utilization sufficiently to provide the increased zinc needs in these stages and, therefore, mitigate immediate detrimental effects due to a low zinc intake. The specific questions addressed are the following: How is zinc utilization altered during pregnancy and lactation? Are those homeostatic adjustments influenced by maternal zinc status, dietary zinc, or zinc supplementation? These questions are addressed by critically reviewing results from published human studies on zinc homeostasis during pregnancy and lactation carried out in different populations worldwide.Keywords
This publication has 99 references indexed in Scilit:
- Marginal Maternal Zinc Deficiency in Lactating Mice Reduces Secretory Capacity and Alters Milk Composition ,Journal of Nutrition, 2012
- Maternal gestational zinc supplementation does not influence multiple aspects of child development at 54 mo of age in PeruThe American Journal of Clinical Nutrition, 2010
- Zip3 (Slc39a3) functions in zinc reuptake from the alveolar lumen in lactating mammary glandAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2009
- Red blood cell metallothionein as an indicator of zinc status during pregnancyNutrition, 2008
- Trace Element Transport in the Mammary GlandAnnual Review of Nutrition, 2007
- The effects of air pollution and smoking on placental cadmium, zinc concentration and metallothionein expressionToxicology, 2007
- Immunobiology of gestational zinc deficiencyBritish Journal of Nutrition, 2001
- Stable isotope metabolic studies of zinc nutrition in slum-dwelling lactating women in the Amazon valleyBritish Journal of Nutrition, 1988
- Iron, Zinc and Folate Status During Pregnancy and Two Months After DeliveryActa Obstetricia et Gynecologica Scandinavica, 1986
- Studies on the absorption of zinc by rat intestineBritish Journal of Nutrition, 1980