Unresectable Primary Tumor of Head and Neck: Does Neck Dissection Combined With Chemoradiotherapy Improve Survival?
- 1 September 2001
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in The Journal of Craniofacial Surgery
- Vol. 12 (5), 438-443
- https://doi.org/10.1097/00001665-200109000-00007
Abstract
A study regarding patients with primary and previously untreated advanced histologically proven squamous cell carcinoma of the head and neck was performed to compare two treatment modalities: neck dissection followed by chemoradiotherapy (Group I) versus chemoradiotherapy alone (Group II). Fifty-four patients were randomly chosen to receive Group I or II treatment. Our results demonstrate that Group I treatment has a higher and statistically significant disease-specific survival rate. We suggest that an association of neck dissection plus chemoradiotherapy can be useful in the event of unresectable advanced carcinomas.Keywords
This publication has 19 references indexed in Scilit:
- Planned neck dissection as an adjunct to the management of patients with advanced neck disease treated with definitive radiotherapy: For some or for all?Head & Neck, 1999
- Management of the neck after alternating chemoradiotherapy for advanced head and neck cancerHead & Neck, 1999
- Management of the neck in a randomized trial comparing concurrent chemotherapy and radiotherapy with radiotherapy alone in resectable stage III and IV squamous cell head and neck cancerHead & Neck, 1997
- Treatment of Advanced Squamous-Cell Carcinoma of the Head and Neck with Alternating Chemotherapy and RadiotherapyThe New England Journal of Medicine, 1992
- Induction Chemotherapy plus Radiation Compared with Surgery plus Radiation in Patients with Advanced Laryngeal CancerThe New England Journal of Medicine, 1991
- Simultaneous Cis-Platinum and Radiotherapy in Inoperable or Locally Advanced Squamous Cell Carcinoma of the Head and NeckOncology, 1991
- Concomitant cisplatin chemotherapy and radiotherapy in advanced mucosal squamous cell carcinoma of the head and neck. Long-term results of the radiation therapy oncology group study 81-17Cancer, 1990
- Integration of chemotherapy in an MFD-radiotherapy plan for advanced inoperable squamous cell carcinoma of the head and neckHead & Neck, 1990
- Concurrent radiotherapy and chemotherapy with cisplatin in inoperable squamous cell carcinoma of the head and neck. An RTOG studyCancer, 1987
- Regional outcome in oropharyngeal and pharyngolaryngeal cancer treated with high dose per fraction radiotherapy. Analysis of neck disease response in 1646 casesRadiotherapy and Oncology, 1986