Clonal relationship between Hashimoto thyroiditis and thyroid lymphoma
- 15 November 2007
- journal article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 61 (4), 438-444
- https://doi.org/10.1136/jcp.2007.051243
Abstract
Background: Although Hashimoto thyroiditis (HT) is a predisposing factor for B-lineage thyroid lymphoma, clonal B-cell populations in HT are rare. Aim: To investigate whether there is a clonal relationship between HT and primary thyroid lymphoma. Methods: Clonalilty and sequence similarity was determined by PCR followed by sequencing and comparing immunoglobulin heavy chain (IgH) gene rearrangement sequences to germline sequences and to each other. Results: 12/20 patients with primary thyroid lymphoma had a previous history and histological diagnosis of HT. Clonal IgH bands associated with a polyclonal background were present in four of these 12 cases of HT; of these four, three had reproducible clonal IgH bands from the subsequently developed lymphoma. The range of similarity (homology) of multiple clonal bands in HT with the germline IgH varied from 90% to 96.3%. Multiple clonal bands in HT had sequence similarity (homology) of 62–100% with the clonal band in the lymphoma from the same patient. At least one clonal band in HT had more than 96% similarity (homology) with the clonal band of lymphoma in all three cases. Conclusion: Sequence similarity between the clonal bands in HT and subsequently developed thyroid lymphoma is supportive of the argument that primary thyroid lymphoma may evolve from HT.Keywords
This publication has 34 references indexed in Scilit:
- Clonal B cell populations in a minority of patients with Hashimoto's thyroiditisJournal of Clinical Pathology, 2004
- Characterization of the lymphoid infiltrate in Hashimoto thyroiditis by immunohistochemistry and polymerase chain reaction for immunoglobulin heavy chain gene rearrangement.American Journal of Clinical Pathology, 1998
- Gapped BLAST and PSI-BLAST: a new generation of protein database search programsNucleic Acids Research, 1997
- Detection of monoclonality in low‐grade B‐cell lymphomas using the polymerase chain reaction is dependent on primer selection and lymphoma typeThe Journal of Pathology, 1993
- Clinical Aspects of Primary Thyroid Lymphoma: Diagnosis and Treatment Based on Our Experience of 119 CasesThyroid®, 1993
- Hashimoto's thyroiditis manifesting monoclonal lymphocytic infiltrationClinical and Experimental Immunology, 1990
- Extranodal noncutaneous lymphoid hyperplasias represent a continuous spectrum of B-cell neoplasia: demonstration by molecular genetic analysisBlood, 1989
- Hashimoto's thyroiditis lacks detectable clonal immunoglobulin and T cell receptor gene rearrangementsHuman Pathology, 1988
- Primary lymphoma of the thyroid: Clinical features, prognostic factors, and results of treatmentInternational Journal of Radiation Oncology*Biology*Physics, 1986
- Cancer Risks in Patients with Chronic Lymphocytic ThyroiditisThe New England Journal of Medicine, 1985