Increased frequencies of CD11b+CD33+CD14+HLA‐DRlow myeloid‐derived suppressor cells are an early event in melanoma patients
Open Access
- 4 February 2014
- journal article
- letter
- Published by Wiley in Experimental Dermatology
- Vol. 23 (3), 202-204
- https://doi.org/10.1111/exd.12336
Abstract
Myeloid‐derived suppressor cells (MDSC) are a heterogeneous cell population characterized by immunosuppressive activity. Elevated levels of MDSC in peripheral blood are found in inflammatory diseases as well as in malignant tumors where they are supposed to be major contributors to mechanisms of tumor‐associated tolerance. We investigated the frequency and function of MDSC in peripheral blood of melanoma patients and observed an accumulation of CD11b+CD33+CD14+HLA‐DRlow MDSC in all stages of disease (I–IV), including early stage I patients. Disease progression and enhanced tumor burden did not result in a further increase in frequencies or change in phenotype of MDSC. By investigation of specific MDSC‐associated cytokines in patients’ sera, we found an accumulation of IL‐8 in all stages of disease. T‐cell proliferation assays revealed that MDSC critically contribute to suppressed antigen‐specific T‐cell reactivity and thus might explain the frequently observed transient effects of immunotherapeutic strategies in melanoma patients.Keywords
Funding Information
- Johannes Gutenberg University Mainz (SFB1066)
- Hiege Stiftung against Melanoma
This publication has 23 references indexed in Scilit:
- Myeloid-derived suppressor cells impair the quality of dendritic cell vaccinesCancer Immunology, Immunotherapy, 2011
- Myeloid derived suppressor cells in human diseasesInternational Immunopharmacology, 2011
- Myeloid-Derived Suppressor Cells in Human CancerThe Cancer Journal, 2010
- Immature Immunosuppressive CD14+HLA-DR−/low Cells in Melanoma Patients Are Stat3hi and Overexpress CD80, CD83, and DC-SignCancer Research, 2010
- IL4Rα+ Myeloid-Derived Suppressor Cell Expansion in Cancer PatientsPublished by The American Association of Immunologists ,2009
- Myeloid-Derived Suppressor Cells: Linking Inflammation and CancerPublished by The American Association of Immunologists ,2009
- Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing MicePublished by The American Association of Immunologists ,2008
- Identification of a New Subset of Myeloid Suppressor Cells in Peripheral Blood of Melanoma Patients With Modulation by a Granulocyte-Macrophage Colony-Stimulation Factor–Based Antitumor VaccineJournal of Clinical Oncology, 2007
- Immunosuppressive Strategies that are Mediated by Tumor CellsAnnual Review of Immunology, 2007
- Myeloid suppressor cells in cancer: Recruitment, phenotype, properties, and mechanisms of immune suppressionSeminars in Cancer Biology, 2005