CuH‐Catalyzed Asymmetric Conjugate Reductions of Acyclic Enones
- 8 October 2003
- journal article
- research article
- Published by Wiley in Angewandte Chemie-International Edition
- Vol. 42 (39), 4789-4792
- https://doi.org/10.1002/anie.200352313
Abstract
A powerful new reaction has been developed for the asymmetric 1,4-reduction of prochiral enones (see scheme). The key ingredients in this exceedingly mild and straightforward procedure are catalytic quantities of CuH, a readily available nonracemic phosphane ligand such as that shown, and inexpensive polymethylhydrosiloxane (PMHS) as the stoichiometric source of hydride.Keywords
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