RUNX1 Mutations in Clonal Myeloid Disorders: From Conventional Cytogenetics to Next Generation Sequencing, A Story 40 Years in the Making
- 1 January 2011
- journal article
- review article
- Published by Begell House in Critical Reviews™ in Oncogenesis
- Vol. 16 (1-2), 77-91
- https://doi.org/10.1615/critrevoncog.v16.i1-2.80
Abstract
Translocations and mutations in the core binding factor genes, RUNX1 or CBFB, are found in acute myeloid and lymphocytic leukemia, therapy-related myeloid leukemia, myelodysplastic syndrome, chronic myelomonocytic leukemia, and in familial platelet disorder with predisposition to acute myeloid leukemia. Here we review the biochemical and biological properties of the normal Runx1 protein, discuss the nature of RUNX1 mutations in myeloid leukemia, their prognostic significance, and the mutations that cooperate or co-exist with them in these various diseases.Keywords
This publication has 99 references indexed in Scilit:
- Structure of the AML1-ETO NHR3–PKA(RIIα) Complex and Its Contribution to AML1-ETO ActivityJournal of Molecular Biology, 2010
- DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid LeukemiaCancer Cell, 2010
- Persistence of Leukemia-Initiating Cells in a Conditional Knockin Model of an Imatinib-Responsive Myeloproliferative DisorderCancer Cell, 2009
- Transforming activity of AML1-ETO is independent of CBFβ and ETO interaction but requires formation of homo-oligomeric complexesProceedings of the National Academy of Sciences of the United States of America, 2009
- Runx1 is required for the endothelial to haematopoietic cell transition but not thereafterNature, 2009
- Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesisProceedings of the National Academy of Sciences of the United States of America, 2008
- Structural Basis for Recognition of SMRT/N-CoR by the MYND Domain and Its Contribution to AML1/ETO's ActivityCancer Cell, 2007
- Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic allelesThe EMBO Journal, 2007
- Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formationThe EMBO Journal, 2006
- The acute myeloid leukemia fusion protein AML1-ETO targets E proteins via a paired amphipathic helix-like TBP-associated factor homology domainProceedings of the National Academy of Sciences of the United States of America, 2006