Pregabalin, celecoxib, and their combination for treatment of chronic low-back pain
Open Access
- 18 November 2009
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of Orthopaedics and Traumatology
- Vol. 10 (4), 185-191
- https://doi.org/10.1007/s10195-009-0077-z
Abstract
Background The efficacy and safety of the association of celecoxib [a selective cyclooxygenase-2 (COX-2) inhibitor] and pregabalin (commonly used to control neuropathic pain), compared with monotherapy of each, were evaluated for the treatment of chronic low-back pain, a condition known to be due to neuropathic as well as nociceptive pain mechanisms. Materials and methods In this prospective randomized trial, 36 patients received three consecutive 4-week treatment regimes, randomly assigned: celecoxib plus placebo, pregabalin plus placebo, and celecoxib plus pregabalin. All patients were assessed by using a visual analogue scale (VAS, 0–100 mm) and the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) pain scale by an investigator blinded to the administered pharmacological treatment. Results Celecoxib and pregabalin were effective in reducing low-back pain when patients were pooled according to LANSS score. The association of celecoxib and pregabalin was more effective than either monotherapy in a mixed population of patients with chronic low-back pain and when data were pooled according to LANSS score. Adverse effects of drug association and monotherapies were similar, with reduced drug consumption in the combined therapy. Conclusions Combination of celecoxib and pregabalin is more effective than monotherapy for chronic low-back pain, with similar adverse effects.Keywords
This publication has 36 references indexed in Scilit:
- Controlled-Release Oxycodone and Pregabalin in the Treatment of Neuropathic Pain: Results of a Multicenter Italian StudyEuropean Neurology, 2008
- Nonsteroidal Anti-Inflammatory Drugs for Low Back PainSpine, 2008
- A Prospective Randomized Trial on the Role of Perioperative Celecoxib Administration for Total Knee Arthroplasty: Improving Clinical Outcomes: RetractedAnesthesia & Analgesia, 2008
- Treatment of painful neuropathyCurrent Opinion in Neurology, 2007
- Medication and treatment use in primary care patients with chronic pain of predominantly neuropathic originFamily Practice, 2007
- Effects of celecoxib on blood loss, pain, and recovery of function after total knee replacement: A randomized placebo-controlled trialActa Orthopaedica, 2007
- Celecoxib Versus Naproxen and Diclofenac in Osteoarthritis Patients: SUCCESS-I StudyAmerican Journal Of Medicine, 2006
- Screening of neuropathic pain components in patients with chronic back pain associated with nerve root compression: a prospective observational pilot study (MIPORT)Current Medical Research and Opinion, 2006
- Towards a mechanism-based classification of pain?Pain, 1998
- The Course of Back Pain in Primary CareSpine, 1996