Biofilms in Chronic Rhinosinusitis: A Review
- 1 May 2009
- journal article
- review article
- Published by SAGE Publications in American Journal of Rhinology and Allergy
- Vol. 23 (3), 255-260
- https://doi.org/10.2500/ajra.2009.23.3319
Abstract
Background Bacterial biofilms consist of a complex, organized community of bacteria that anchor to both biotic and abiotic surfaces. They are composed of layers of embedded, live bacteria within extruded exopolymeric matrix. This configuration allows for evasion of host defenses and decreased susceptibility to antibiotic therapy while maintaining the ability to deliberately release planktonic bacteria, resulting in recurrent acute infections. Thus, bacterial biofilms were hypothesized to contribute to the progression and persistence of chronic rhinosinusitis. Methods This review summarizes several of the seminal papers supporting this hypothesis. Results Multiple reports using various imaging modalities have demonstrated the presence of biofilms in sinonasal mucosa of patients with chronic rhinosinusitis. More recently, several studies have correlated the presence of biofilms with poor clinical outcomes in the disease process. Early therapeutic interventions have generated mixed results. Conclusions Bacterial biofilms appear to contribute to the progression of chronic rhinosinusitis in a subset of patients, although substantial effort toward therapeutic intervention is still necessary.Keywords
This publication has 38 references indexed in Scilit:
- Nasal Lavage With Mupirocin for the Treatment of Surgically Recalcitrant Chronic RhinosinusitisThe Laryngoscope, 2008
- Prevalence of Biofilm-forming Bacteria in Chronic RhinosinusitisAmerican Journal of Rhinology, 2008
- In Vitro Activity of Mupirocin on Clinical Isolates of Staphylococcus aureus and its Potential Implications in Chronic RhinosinusitisThe Laryngoscope, 2008
- Methods for Removing Bacterial Biofilms: In Vitro Study using Clinical Chronic Rhinosinusitis SpecimensAmerican Journal of Rhinology, 2007
- Evaluation of the in vivo efficacy of topical tobramycin against Pseudomonas sinonasal biofilmsJournal of Antimicrobial Chemotherapy, 2007
- Effectiveness of Topical Antibiotics on Staphylococcus Aureus Biofilm in VitroAmerican Journal of Rhinology, 2007
- Persister cells, dormancy and infectious diseaseNature Reviews Microbiology, 2006
- Survival strategies of infectious biofilmsTrends in Microbiology, 2005
- Editors and Reviewers: Supporting Peer-Review PublishingOtolaryngology -- Head and Neck Surgery, 2003
- Candidate's Thesis: Direct Evidence of Bacterial Biofilms in Otitis MediaThe Laryngoscope, 2001