Ubiquitin-like protein activation
- 15 March 2004
- journal article
- review article
- Published by Springer Science and Business Media LLC in Oncogene
- Vol. 23 (11), 1958-1971
- https://doi.org/10.1038/sj.onc.1207393
Abstract
Post-translational covalent attachment of ubiquitin and ubiquitin-like proteins (ubls) has emerged as a predominant cellular regulatory mechanism, with important roles in controlling cell division, signal transduction, embryonic development, endocytic trafficking and the immune response. Ubls function by remodeling the surface of their target proteins, changing their target's half-life, enzymatic activity, protein–protein interactions, subcellular localization or other properties. At least 10 different ubiquitin-like modifications exist in mammals, and attachment of different ubls to a target leads to different biological consequences. Ubl-conjugation cascades are initiated by activating enzymes, which also coordinate the ubls with their downstream pathways. A number of biochemical and structural studies have provided insights into the mechanism of ubl-activating enzymes and their roles in ubl conjugation cascades.Keywords
This publication has 103 references indexed in Scilit:
- Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8Nature, 2003
- RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMONature, 2002
- Structural Basis for E2-Mediated SUMO Conjugation Revealed by a Complex between Ubiquitin-Conjugating Enzyme Ubc9 and RanGAP1Cell, 2002
- Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin ChainCell, 2000
- De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndromeNature Genetics, 1997
- UBE3A/E6-AP mutations cause Angelman syndromeNature Genetics, 1997
- A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase.Proceedings of the National Academy of Sciences of the United States of America, 1995
- The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzymeNature, 1987
- Structure of ubiquitin refined at 1.8 Å resolutionJournal of Molecular Biology, 1987
- Chemical and biological evolution of a nucleotide-binding proteinNature, 1974