Sleep and benzodiazepine receptor sub-types
- 1 September 1987
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of Neural Transmission
- Vol. 70 (3-4), 329-336
- https://doi.org/10.1007/bf01253607
Abstract
CL 218,872, which preferentially binds to benzodiazepine (BZ) type 1 receptors, and flurazepam, which is thought to bind to both types 1 and 2, were given alone and in combination to rats. CL 218,872 had little effect on sleep latency, but significantly increased total sleep time. As expected, flurazepam both shortened sleep latency and prolonged total sleep. Pretreatment with CL 218,872 had no effect on these alterations in sleep induced by flurazepam. The implications for possible significance of sub-typing of BZ receptors are discussed.Keywords
This publication has 15 references indexed in Scilit:
- Pre‐ Versus Postsynaptic Localization of Benzodiazepine and β‐Carboline Binding SitesJournal of Neurochemistry, 1985
- A comparison between chlordiazepoxide and CL 218,872?a synthetic nonbenzodiazepine ligand for benzodiazepine receptors on spontaneous locomotor activity in ratsPsychopharmacology, 1985
- The benzodiazepine receptor ligand CL218,872 has both anxiolytic and sedative properties in rodentsNeuropharmacology, 1984
- Differential localization of type I and type II benzodiazepine binding sites in substantia nigraNature, 1983
- Multiple benzodiazepine receptors: Structures in the brain or structures in the mind? A critical reviewLife Sciences, 1983
- Multiple benzodiazepine receptor localization by light microscopic radiohistochemistry.1981
- A synthetic non-benzodiazepine ligand for benzodiazepine receptors: A probe for investigating neuronal substrates of anxietyPharmacology Biochemistry and Behavior, 1979
- Benzodiazepine receptors: Cellular and behavioral characteristicsPharmacology Biochemistry and Behavior, 1979
- Sleep during chronic ethanol administration and withdrawal in rats.Journal of Studies on Alcohol, 1978
- The flower pot technique of Rapid Eye Movement (REM) sleep deprivationPharmacology Biochemistry and Behavior, 1974