New Insights into IL-10 Dependent and IL-10 Independent Mechanisms of Regulatory B Cell Immune Suppression
- 23 March 2016
- journal article
- review article
- Published by Springer Science and Business Media LLC in Journal of Clinical Immunology
- Vol. 36 (S1), 25-33
- https://doi.org/10.1007/s10875-016-0263-8
Abstract
Regulatory B (Breg) cells are important regulators of immune responses and in recent years our understanding of their phenotypical and functional characteristics has improved considerably. Initially all suppressive capabilities of Breg cells were attributed to the actions of the anti-inflammatory cytokine interleukin (IL)-10 secreted by Breg cells. Recent studies however, highlight additional and novel mechanisms that influence both the expansion of Breg cells and their capacity to suppress immunity. Here we provide an overview of the complexity of Breg cell populations and address the newly discovered IL-10 independent mechanisms of Breg cell expansion and immune-suppression.Keywords
Funding Information
- Science Foundation Ireland
- National Children's Research Centre
- Irish Research Council
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