Antibiotics from Basidiomycetes. XIII The alliacols A and B from Maramius alliaceus (JACQ ex Fr.) Fr.

Abstract

Two antimicrobial and cytotoxic metabolites were isolated from fermentation broth of M. alliaceus. The structures of the 2 crystalline antibiotics, alliacols A (6) and B (1) were elucidated by spectroscopic methods and chemical correlation with alliacolide (3). The alliacols show weak antibacterial and antifungal activity. Both antibiotics strongly inhibit DNA synthesis in cells of the ascitic form of [mouse] Ehrlich carcinoma at concentrations of 2-5 .mu.g/ml. Alliacols A and B react with cysteine to form adducts with strongly reduced biological activities.