Effects of cardiac resynchronization therapy on disease progression in chronic heart failure
Open Access
- 27 January 2006
- journal article
- review article
- Published by Oxford University Press (OUP) in European Heart Journal
- Vol. 27 (9), 1018-1025
- https://doi.org/10.1093/eurheartj/ehi734
Abstract
Despite the alleviation of symptoms and longer survival conferred by pharmacological management of chronic congestive heart failure (CHF), this progressive syndrome remains associated with high morbidity and premature death. A new treatment of CHF should ideally alleviate symptoms, improve functional capacity, decrease mortality, and slow or reverse its progression without adding risks for the patient that outweighs the benefits. Growing evidence indicates that devices implanted to resynchronize ventricular contraction are a beneficial adjunct in the treatment of CHF. This review discusses the remodelling process, and its clinical and prognostic significance. We also discuss the impact of CRT, on remodelling and disease progression with a particular focus on patients with asymptomatic or mild heart failure (NYHA Class I-II).Keywords
This publication has 58 references indexed in Scilit:
- The Effect of Cardiac Resynchronization on Morbidity and Mortality in Heart FailureNew England Journal of Medicine, 2005
- Systematic Review: Cardiac Resynchronization in Patients with Symptomatic Heart FailureAnnals of Internal Medicine, 2004
- Cardiac-Resynchronization Therapy with or without an Implantable Defibrillator in Advanced Chronic Heart FailureNew England Journal of Medicine, 2004
- Heart FailureNew England Journal of Medicine, 2003
- Effect of Cardiac Resynchronization Therapy on Left Ventricular Size and Function in Chronic Heart FailureCirculation, 2003
- Left ventricular remodelling and haemodynamic effects of multisite biventricular pacing in patients with left ventricular systolic dysfunction and activation disturbances in sinus rhythm: sub-study of the MUSTIC (Multisite Stimulationin Cardiomyopathies) trial,Published by Oxford University Press (OUP) ,2003
- Long-term benefits of biventricular pacing in congestive heart failure: results from the MUltisite STimulation in cardiomyopathy (MUSTIC) studyJournal of the American College of Cardiology, 2002
- Cardiac Resynchronization in Chronic Heart FailureNew England Journal of Medicine, 2002
- Effects of Multisite Biventricular Pacing in Patients with Heart Failure and Intraventricular Conduction DelayNew England Journal of Medicine, 2001
- Cardiac remodeling—concepts and clinical implications: a consensus paper from an international forum on cardiac remodelingJournal of the American College of Cardiology, 2000