Transmembrane Helical Interactions and the Assembly of the T Cell Receptor Complex
- 19 July 1990
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 249 (4966), 274-277
- https://doi.org/10.1126/science.2142801
Abstract
Studies of the subunit interactions of the multicomponent T cell antigen receptor (TCR) revealed that specific pairs of chains have the ability to assemble after transfection into fibroblasts. For one such pair, TCR-alpha and CD3-delta, their ability to assemble was encoded by their transmembrane domains. The specificity of this interaction suggests that well-defined helical interactions in the membrane can explain the assembly of some multichain membrane complexes.This publication has 25 references indexed in Scilit:
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