Integrated acoustic and magnetic separation in microfluidic channels
- 21 December 2009
- journal article
- research article
- Published by AIP Publishing in Applied Physics Letters
- Vol. 95 (25), 254103
- https://doi.org/10.1063/1.3275577
Abstract
With a growing number of cell-based biotechnological applications, there is a need for particle separation systems capable of multiparameter separations at high purity and throughput, beyond what is presently offered by traditional methods including fluorescence activated cell sorting and column-based magnetic separation. Toward this aim, we report on the integration of microfluidic acoustic and magnetic separation in a monolithic device for multiparameter particle separation. Using our device, we demonstrate high-purity separation of a multicomponent particle mixture at a throughput of up to 108 particles/hr.Keywords
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