Synthesis and Antimicrobial Evaluation of Some Novel 2‐Aminothiazole Derivatives of 4‐Hydroxy‐chromene‐2‐one
- 11 July 2008
- journal article
- Published by Wiley in Archiv der Pharmazie
- Vol. 341 (8), 491-496
- https://doi.org/10.1002/ardp.200700215
Abstract
Syntheses of 2‐aminothiazole derivatives of 4‐hydroxy‐chromene‐2‐one 2c–10c are reported in this paper. These compounds 2c–10c were prepared from 3‐(2‐bromoacetyl)‐4‐hydroxy‐chromene‐2‐one 1 and corresponding thiourea derivatives 2b–10b using Hantzsch reaction. The structures of all compounds were confirmed by IR and 1H‐NMR spectroscopy and elemental analyses. The molecules 2c–10c were evaluated for in vitro antimicrobial activity against ten bacteria and twelve fungi. All tested compounds exhibited antibacterial and antifungal activity.Keywords
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