Risk factors for early death after liver resection in patients with solitary hepatocellular carcinoma
- 28 October 2005
- journal article
- Published by Springer Science and Business Media LLC in Journal of Hepato-Biliary-Pancreatic Surgery
- Vol. 12 (5), 399-404
- https://doi.org/10.1007/s00534-005-1009-9
Abstract
Although most patients who receive hepatectomy for a solitary hepatocellular carcinoma (HCC) have a relatively fair result, some have a poor prognosis. The aim of this study was to evaluate the risk factors for early death after hepatectomy in patients with a solitary HCC. Eligible patients (n = 110) who had undergone hepatectomy for solitary HCC between 1990 and 2002 and were able to be followed up for more than 2 years after the hepatectomy were divided into two groups, those who died of cancer recurrence within 2 years (early-death group; n = 18) and those who survived for more than 2 years after the surgery (survival group; n = 92). Risk factors for early death after liver resection were evaluated by univariate and multivariate analyses. The gross tumor classification, tumor diameter, macroscopic portal vein invasion, microscopic growth pattern, microscopic vascular invasion (MVI), and the width of the surgical margin were significant (P < 0.05) factors by univariate analysis. Multivariate analysis showed that the presence of MVI was an independent and significant risk factor for early death of recurrence. Among patients with solitary HCC, the presence of MVI indicates a poor prognosis. These patients need adjuvant chemotherapy in the early period after hepatectomy.Keywords
This publication has 19 references indexed in Scilit:
- Risk factors for early death due to recurrence after liver resection for hepatocellular carcinoma: Results of a multicenter studyJournal of Surgical Oncology, 2003
- Computed tomographic features of hepatocellular carcinoma predict long-term survival after hepatic resectionEuropean Journal of Surgical Oncology, 2002
- Estimation of prognosis after hepatectomy for hepatocellular carcinomaBritish Journal of Surgery, 2002
- Prognostic factors and survival after hepatic resection for hepatocellular carcinoma without cirrhosisBritish Journal of Surgery, 2001
- Different risk factors and prognosis for early and late intrahepatic recurrence after resection of hepatocellular carcinomaCancer, 2000
- What Patients Can Survive Disease Free After Complete Resection for Hepatocellular Carcinoma?: A Multivariate AnalysisJapanese Journal of Clinical Oncology, 2000
- Patterns of recurrence after initial treatment in patients with small hepatocellular carcinomaJournal of Hepatology, 1997
- The Potential Role of Postoperative Hepatic Artery Chemotherapy in Patients with High-risk HepatomasAnnals of Surgery, 1991
- Pathologic Characteristics of Hepatocellular CarcinomaSeminars in Liver Disease, 1986
- Transection of the oesophagus for bleeding oesophageal varicesBritish Journal of Surgery, 1973