PHGDH amplification and altered glucose metabolism in human melanoma
- 28 October 2011
- journal article
- review article
- Published by Wiley in Pigment Cell & Melanoma Research
- Vol. 24 (6), 1112-1115
- https://doi.org/10.1111/j.1755-148x.2011.00919.x
Abstract
The metabolic requirements of cancer cells differ from that of their normal counterparts. To support their proliferation, cancer cells switch to a fermentative metabolism that is thought to support biomass production. Instances where metabolic enzymes promote tumorigenesis remain rare. However, an enzyme involved in the de novo synthesis of serine, 3-phosphoglycerate dehydrogenase (PHGDH), was recently identified as a putative oncogene. The potential mechanisms by which PHGDH promotes cancer are discussed.Keywords
This publication has 31 references indexed in Scilit:
- Ammonia-induced autophagy is independent of ULK1/ULK2 kinasesProceedings of the National Academy of Sciences of the United States of America, 2011
- The landscape of somatic copy-number alteration across human cancersNature, 2010
- Cancer-associated IDH1 mutations produce 2-hydroxyglutarateNature, 2009
- Q's next: the diverse functions of glutamine in metabolism, cell biology and cancerOncogene, 2009
- The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growthNature, 2008
- Brick by brick: metabolism and tumor cell growthCurrent Opinion in Genetics & Development, 2008
- The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and ProliferationCell Metabolism, 2008
- Modelling glandular epithelial cancers in three-dimensional culturesNature Reviews Cancer, 2005
- Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane culturesMethods, 2003
- l-Serine in disease and developmentBiochemical Journal, 2003