Aldosterone Paradox: Differential Regulation of Ion Transport in Distal Nephron
- 1 April 2011
- journal article
- review article
- Published by American Physiological Society in Physiology
- Vol. 26 (2), 115-123
- https://doi.org/10.1152/physiol.00049.2010
Abstract
The mechanisms through which aldosterone promotes apparently opposite effects like salt reabsorption and K+secretion remain poorly understood. The identification, localization, and physiological analysis of ion transport systems in distal nephron have revealed an intricate network of interactions between several players, revealing the complex mechanism behind the aldosterone paradox. We review the mechanisms involved in differential regulation of ion transport that allow the fine tuning of salt and K+balance.Keywords
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