The metabolic life and times of a T‐cell
- 15 June 2010
- journal article
- review article
- Published by Wiley in Immunological Reviews
- Vol. 236 (1), 190-202
- https://doi.org/10.1111/j.1600-065x.2010.00911.x
Abstract
Summary: The regulation of lymphocyte homeostasis is critical for the development and formation of productive immune responses. Cell numbers must be maintained to allow sufficient numbers of lymphocytes to combat foreign pathogens but prevent the accumulation of excess lymphocytes that may increase the risk of developing autoimmunity or neoplasia. Cell extrinsic growth factors are essential to maintain homeostasis and cell survival, and it has become increasingly apparent that a key mechanism of this control is through regulation of cell metabolism. The metabolic state of T cells can have profound influences on cell growth and survival and even differentiation. In particular, resting T cells utilize an energy efficient oxidative metabolism but shift to a highly glycolytic metabolism when stimulated to grow and proliferate by pathogen encounter. After antigen clearance, T cells must return to a more quiescent oxidative metabolism to support T‐cell memory. This review highlights how these metabolic changes may be intricately involved with both T‐cell growth and death in the control of homeostasis and immunity.Keywords
This publication has 131 references indexed in Scilit:
- Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and BaxBiochemical Pharmacology, 2009
- Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parametersNature Medicine, 2009
- mTOR regulates memory CD8 T-cell differentiationNature, 2009
- Enhancing CD8 T-cell memory by modulating fatty acid metabolismNature, 2009
- The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage CommitmentImmunity, 2009
- Surviving the crash: Transitioning from effector to memory CD8+ T cellSeminars in Immunology, 2009
- Apoptosis Regulators Fas and Bim Cooperate in Shutdown of Chronic Immune Responses and Prevention of AutoimmunityImmunity, 2008
- Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription FactorImmunity, 2007
- Differential contribution of Puma and Noxa in dual regulation of p53-mediated apoptotic pathwaysThe EMBO Journal, 2006
- Cell DeathCell, 2004