Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics
- 1 September 1990
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 347 (6289), 146-151
- https://doi.org/10.1038/347146a0
Abstract
A dopamine receptor has been characterized which differs in its pharmacology and signalling system from the D1 or D2 receptor and represents both an autoreceptor and a postsynaptic receptor. The D3 receptor is localized to limbic areas of the brain, which are associated with cognitive, emotional and endocrine functions. It seems to mediate some of the effects of antipsychotic drugs and drugs used against Parkinson's disease, that were previously thought to interact only with D2 receptors.Keywords
This publication has 41 references indexed in Scilit:
- G Proteins in Signal TransductionAnnual Review of Pharmacology and Toxicology, 1990
- Organization and expression of the Rat D2A receptor gene: identification of alternative transcripts and a variant donor splice siteBiochemistry, 1990
- Multiple D2 dopamine receptors produced by alternative RNA splicingNature, 1989
- Alternative splicing directs the expression of two D2 dopamine receptor isoformsNature, 1989
- Cloning and expression of a rat D2 dopamine receptor cDNANature, 1988
- A family of receptors coupled to guanine nucleotide regulatory proteinsBiochemistry, 1987
- Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionAnalytical Biochemistry, 1987
- Isolation of biologically active ribonucleic acid from sources enriched in ribonucleaseBiochemistry, 1979
- Multiple receptors for dopamineNature, 1979
- Antipsychotic drug doses and neuroleptic/dopamine receptorsNature, 1976