The elastic resilience of DNA can induce all‐or‐none structural transitions in the nucleosome core particle
- 1 November 1991
- journal article
- research article
- Published by Wiley in Peptide Science
- Vol. 31 (13), 1543-1557
- https://doi.org/10.1002/bip.360311310
Abstract
DNA on the surface of the histone octamer in the native nucleosome core particle is modeled as a circumferentially wound elastic line on the surface of a cylinder. In a model for the radial transition, the line is allowed to straighten, and thus lose energy, by swinging off the surface, but it is impeded in such an excursion by a radial force field representing the attractive interaction between DNA and histone octamer. In a model for the axial transition, the line may straighten by becoming more parallel to a generator of the cylinder while remaining on the surface. In this mode of straightening, dimer–tetramer or tetramer–tetramer interfaces are disrupted, and the resulting energy gain impedes the transition. Both radial and axial transitions are predicted to occur in all-or-none fashion. We propose that these models are related to the abrupt transitions actually observed in the nucleosome core particle.Keywords
This publication has 21 references indexed in Scilit:
- Toward a Unified Model of Chromatin FoldingAnnual Review of Biophysics and Biophysical Chemistry, 1989
- Elastic line deformed on a surface by an external field: Intrinsic formulation and preliminary application to nucleosome energeticsPhysical Review A, 1988
- Structure of the nucleosome core particle at 7 Å resolutionNature, 1984
- Neutron scattering studies of nucleosome structure at low ionic strengthBiochemistry, 1983
- Breathing and bending fluctuations in DNA modeled by an open‐base‐pair kink coupled to axial compressionPeptide Science, 1983
- Unfolding of 175-base-pair nucleosomesBiochemistry, 1982
- A procedure for extracting persistence lengths from light‐scattering data on intermediate molecular weight DNAPeptide Science, 1981
- Unfolding of nucleosomes by ethidium bindingBiochemistry, 1980
- Structural changes of nucleosomes in low-salt concentrationsBiochemistry, 1979
- Flexibility of native DNA from the sedimentation behavior as a function of molecular weight and temperatureJournal of Molecular Biology, 1968