MRI pattern approach of adult-onset inherited leukoencephalopathies

Abstract

White matter hyperintensities are frequently encountered in clinical practice. In adulthood, white matter hyperintensities are generally related to acquired disorders, such as vascular, inflammatory, or demyelinating diseases. Symmetrical and confluent white matter abnormalities on the first available MRI suggest a genetic disorder. In this article, we provide keys to recognize and classify the adult-onset forms of inherited leukoencephalopathies and to identify their causes by targeting specific biochemical or molecular biomarkers.